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CDC25A governs proliferation and differentiation of FLT3-ITD acute myeloid leukemia

Archive ouverte | Bertoli, Sarah | CCSD

International audience

CDC25A governs proliferation and differentiation of FLT3-ITD acute myeloid leukemia

Archive ouverte | Bertoli, Sarah | CCSD

We investigated cell cycle regulation in acute myeloid leukemia cells expressing the FLT3-ITD mutated tyrosine kinase receptor, an underexplored field in this disease. Upon FLT3 inhibition, CDC25A mRNA and protein were rapidly dow...

CHK1 as a therapeutic target to bypass chemoresistance in AML

Archive ouverte | David, Laure | CCSD

International audience. AML patients have new hope for overcoming resistance to therapy by inhibiting the DNA checkpoint kinase CHK1.

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