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Differential astrocyte and oligodendrocyte vulnerability in murine Creutzfeldt-Jakob disease

Archive ouverte | Andrés-Benito, Pol | CCSD

International audience. Glial vulnerability to prions is assessed in murine Creutzfeldt-Jakob disease (CJD) using the tg340 mouse line expressing four-fold human PrP M129 levels on a mouse PrP null background at dif...

Assessment of Glial Activation Response in the Progress of Natural Scrapie after Chronic Dexamethasone Treatment

Archive ouverte | Guijarro, Isabel | CCSD

International audience. Neuroinflammation has been correlated with the progress of neurodegeneration in many neuropathologies. Although glial cells have traditionally been considered to be protective, the concept of...

Neuroimmune Response Mediated by Cytokines in Natural Scrapie after Chronic Dexamethasone Treatment

Archive ouverte | Guijarro, Isabel | CCSD

International audience. The actual role of prion protein-induced glial activation and subsequent cytokine secretion during prion diseases is still incompletely understood. The overall aim of this study is to assess ...

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