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Improved Synthesis and Preparation of Analogues of a Pain-Relieving Pyridin-2(1H)-one

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Frazier, Théo | Murail, Pauline | Giraud, Francis | Artola, Alain | Dallel, Radhouane | Anizon, Fabrice | Moreau, Pascale

Edité par CCSD ; Georg Thieme Verlag -

International audience. An optimization of the synthesis of 3,5-disubstituted pyridin-2(1H)-ones with in vivo anti-allodynic activity was conducted. The optimized synthesis was employed to prepare novel analogues which were then assessed for their efficacy in preventing cutaneous mechanical allodynia in a male rat hindpaw capsaicin model.

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