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Pyridin-2(1H)one derivatives: A possible new class of therapeutics for mechanical allodynia

Archive ouverte | Visseq, Alexia | CCSD

International audience. Mechanical Allodynia (MA), a frequent chronic pain symptom caused by innocuous stimuli, constitutes an unmet medical need, as treatments using analgesics available today are not always effect...

Improved potency of pyridin-2(1H)one derivatives for the treatment of mechanical allodynia

Archive ouverte | Visseq, Alexia | CCSD

International audience. Mechanical allodynia, a painful sensation caused by innocuous touch, is a major chronic pain symptom, which often remains without an effective treatment. There is thus a need for new antiallo...

Improved Synthesis and Preparation of Analogues of a Pain-Relieving Pyridin-2(1H)-one

Archive ouverte | Frazier, Théo | CCSD

International audience. An optimization of the synthesis of 3,5-disubstituted pyridin-2(1H)-ones with in vivo anti-allodynic activity was conducted. The optimized synthesis was employed to prepare novel analogues wh...

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