Syracuse

Amino-acid PET as a prognostic tool after post Stupp protocol temozolomide therapy in high-grade glioma patients

Archive ouverte

Zinsz, Adeline | Ahrari, Shamimeh | Becker, Jason | Mortada, Ali | Roch, Veronique | Doriat, Louis | Santi, Matthieu | Blonski, Marie | Taillandier, Luc | Zaragori, Timothée | Verger, Antoine

Edité par CCSD ; Springer Verlag -

International audience. Purpose: This study aimed to evaluate the prognostic performance of amino-acid PET in high-grade gliomas (HGG) patients at the time of temozolomide (TMZ) treatment discontinuation, after the Stupp protocol. Methods: The analysis included consecutive HGG patients with dynamic [18F]FDOPA PET imaging within 3 months of the end of TMZ therapy, post-Stupp protocol. Static and dynamic PET parameters, responses to RANO criteria for MRI and clinical and histo-molecular factors were correlated to progression-free (PFS). Results: Thirty-two patients (59.4 [54.0;67.6] years old, 13 (41%) women) were included. Static PET parameters peak tumor-to-background ratio and metabolic tumor volume (respective thresholds of 1.9 and 1.5 mL) showed the best 84% accuracies for predicting PFS at 6 months (p = 0.02). These static PET parameters were also independent predictor of PFS in multivariate analysis (p ≤ 0.05). Conclusion In HGG patients having undergone a Stupp protocol, the absence of significant PET uptake after TMZ constitutes a favorable prognostic factor.

• Description
• Sujet/Public
• Outil
• Outil d'anticipation
• Mémoire et thèse
• Gestion