Poly-pharmacology of existing drugs: How to crack the code?

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Mouysset, Baptiste | Le Grand, Marion | Camoin, Luc | Pasquier, Eddy

Edité par CCSD ; Elsevier -

International audience. Drug development in oncology is highly challenging, with less than 5% success rate in clinical trials. This alarming figure points out the need to study in more details the multiple biological effects of drugs in specific contexts. Indeed, the comprehensive assessment of drug poly-pharmacology can provide insights into their therapeutic and adverse effects, to optimize their utilization and maximize the success rate of clinical trials. Recent technological advances have made possible in-depth investigation of drug poly-pharmacology. This re- view first highlights high-throughput methodologies that have been used to unveil new mechanisms of action of existing drugs. Then, we discuss how emerging chemo-proteomics strategies allow effectively dissecting the poly- pharmacology of drugs in an unsupervised manner.

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