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Combination drug screen targeting glioblastoma core vulnerabilities reveals pharmacological synergisms

Archive ouverte | Ariey-Bonnet, Jérémy | CCSD

International audience. BackgroundPharmacological synergisms are an attractive anticancer strategy. However, with more than 5000 approved-drugs and compounds in clinical development, identifying synergistic treatmen...

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Archive ouverte | Le Grand, Marion | CCSD

International audience. Metabolic reprogramming is a hallmark of cancer development, mediated by genetic and epigenetic alterations that may be pharmacologically targeted. Among oncogenes, the kinase Akt is commonly...

End-binding 1 protein overexpression correlates with glioblastoma progression and sensitizes to Vinca-alkaloids in vitro and in vivo

Archive ouverte | Berges, Raphael | CCSD

International audience. End-binding 1 protein (EB1) is a key player in the regulation of microtubule (MT) dynamics. Here, we investigated the role of EB1 in glioblastoma (GBM) tumor progression and its potential pre...

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