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The Early Life Microbiota Is Not a Major Factor Underlying the Susceptibility to Postweaning Diarrhea in Piglets
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Edité par CCSD ; American Society for Microbiology -
International audience. Postweaning diarrhea (PWD) in piglets impair welfare, induce economic lossesand lead to overuse of antibiotics. The early life gut microbiota was proposed to contributeto the susceptibility to PWD. The objective of our study was to evaluate in a large cohortof 116 piglets raised in 2 separate farms whether the gut microbiota composition andfunctions during the suckling period were associated with the later development of PWD.The fecal microbiota and metabolome were analyzed by 16S rRNA gene ampliconsequencing and nuclear magnetic based resonance at postnatal day 13 in male andfemale piglets. The later development of PWD was recorded for the same animals fromweaning (day 21) to day 54. The gut microbiota structure anda-diversity during the suck-ling period were not associated with the later development of PWD. There was no signifi-cant difference in the relative abundances of bacterial taxa in suckling piglets that laterdeveloped PWD. The predicted functionality of the gut microbiota and the fecal metabo-lome signature during the suckling period were not linked to the later development ofPWD. Trimethylamine was the bacterial metabolite which fecal concentration during thesuckling period was the most strongly associated with the later development of PWD.However, experiments in piglet colon organoids showed that trimethylamine did notdisrupt epithelial homeostasis and is thus not likely to predispose to PWD through thismechanism. In conclusion, our data suggest that the early life microbiota is not a majorfactor underlying the susceptibility to PWD in piglets.
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