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A supramolecular assembly mediates lentiviral DNA integration

Archive ouverte | Ballandras-Colas, Allison | CCSD

International audience. High-resolution insights into the intasome An essential step in the life cycle of lentiviruses such as HIV-1 is when viral DNA integrates into the host genome, establishing a permanent infect...

Structural basis for the inhibition of HTLV-1 integration inferred from cryo-EM deltaretroviral intasome structures

Archive ouverte | Barski, Michal | CCSD

International audience. Abstract Between 10 and 20 million people worldwide are infected with the human T-cell lymphotropic virus type 1 (HTLV-1). Despite causing life-threatening pathologies there is no therapeutic...

Biochemical Characterization of Novel Retroviral Integrase Proteins

Archive ouverte | Ballandras-Colas, Allison | CCSD

International audience. Integrase is an essential retroviral enzyme, catalyzing the stable integration of reverse transcribed DNA into cellular DNA. Several aspects of the integration mechanism, including the length...

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