A supramolecular assembly mediates lentiviral DNA integration

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Ballandras-Colas, Allison | Maskell, Daniel | Serrao, Erik | Locke, Julia | Swuec, Paolo | Jónsson, Stefán | Kotecha, Abhay | Cook, Nicola | Pye, Valerie | Taylor, Ian | Andrésdóttir, Valgerdur | Engelman, Alan | Costa, Alessandro | Cherepanov, Peter

Edité par CCSD ; American Association for the Advancement of Science (AAAS) -

International audience. High-resolution insights into the intasome An essential step in the life cycle of lentiviruses such as HIV-1 is when viral DNA integrates into the host genome, establishing a permanent infection of the host cell. The viral integrase enzyme catalyzes this process and is a major drug target. During viral integration, integrase binds the ends of viral DNA, forming a higher-order structure called the intasome. Passos et al. and Ballandras-Colas et al. used cryo—electron microscopy to solve the structures of the intasomes from HIV-1 and maedi-visna virus (ovine lentivirus), respectively. These structures reveal how integrase self-associates to form a functional intasome and help resolve previous conflicting models of intasome assembly. Science , this issue p. 89 , p. 93

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