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Rational-Differential Design of Highly Specific Glycomimetic Ligands: Targeting DC-SIGN and Excluding Langerin Recognition

Archive ouverte | Porkolab, Vanessa | CCSD

International audience. At the surface of dendritic cells, C-type lectin receptors (CLRs) allow the recognition of carbohydrate-based PAMPS or DAMPS (pathogen- or danger-associated molecular patterns, respectively) ...

Development of C-type lectin-oriented surfaces for high avidity glycoconjugates: towards mimicking multivalent interactions on the cell surface

Archive ouverte | Porkolab, Vanessa | CCSD

International audience. Multivalent interactions between complex carbohydrates and oligomeric C-type lectins govern a wide range of immune responses. Up to date, standard SPR (surface plasmon resonance) competitive ...

Designing nanomolar antagonists of DC-SIGN-mediated HIV infection: ligand presentation using molecular rods.

Archive ouverte | Ordanini, Stefania | CCSD

International audience. DC-SIGN antagonists were designed combining one selective monovalent glycomimetic ligand with trivalent dendrons separated by a rigid core of controlled length. The design combines multiple m...

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