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Designing nanomolar antagonists of DC-SIGN-mediated HIV infection: ligand presentation using molecular rods.

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Ordanini, Stefania | Varga, Norbert | Porkolab, Vanessa | Thépaut, Michel | Belvisi, Laura | Bertaglia, Andrea | Palmioli, Alessandro | Berzi, Angela | Trabattoni, Daria | Clerici, Mario | Fieschi, Franck | Bernardi, Anna

Edité par CCSD ; Royal Society of Chemistry -

International audience. DC-SIGN antagonists were designed combining one selective monovalent glycomimetic ligand with trivalent dendrons separated by a rigid core of controlled length. The design combines multiple multivalency effects to achieve inhibitors of HIV infection, which are active in nanomolar concentration.

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