Cortical neuronal assemblies coordinate with EEG microstate dynamics during resting wakefulness

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Boyce, Richard | Dard, Robin, F | Cossart, Rosa

Edité par CCSD ; Elsevier Inc -

International audience. The disruption of cortical assembly activity has been associated with anesthesia-induced loss of consciousness. However, the relationship between cortical assembly activity and the variations in consciousnessassociated with natural vigilance states remains unclear. Here, we address this by performing vigilancestate-specific clustering analysis on 2-photon calcium imaging data from the sensorimotor cortex in combination with global electroencephalogram (EEG) microstate analysis derived from multi-EEG signals obtainedover widespread cortical locations. We report no difference in the structure of assembly activity during quietwakefulness (QW), non-rapid eye movement sleep (NREMs), or REMs, despite the latter two vigilance statesbeing associated with significantly reduced levels of consciousness relative to QW. However, we describe asignificant coordination between global EEG microstate dynamics and general local cortical assembly activity during periods of QW, but not sleep. These results suggest that the coordination of cortical assembly activity with global brain dynamics could be a key factor of sustained conscious experience.

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