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Assessing personalized responses to anti-PD-1 treatment using patient-derived lung tumor-on-chip

Archive ouverte | Veith, Irina | CCSD

International audience. There is a compelling need for approaches to predict the efficacy of immunotherapy drugs. Tumor-on-chip technology exploits microfluidics to generate 3D cell co-cultures embedded in hydrogels...

Apoptosis mapping in space and time of 3D tumor ecosystems reveals transmissibility of cytotoxic cancer death

Archive ouverte | Veith, Irina | CCSD

International audience. The emerging tumor-on-chip (ToC) approaches allow to address biomedical questions out of reach with classical cell culture techniques: in biomimetic 3D hydrogels they partially reconstitute e...

Dissecting Effects of Anti-cancer Drugs and Cancer-Associated Fibroblasts by On-Chip Reconstitution of Immunocompetent Tumor Microenvironments

Archive ouverte | Nguyen, Marie | CCSD

International audience. Graphical Abstract Highlights d A complex HER2 + breast cancer ecosystem is reconstituted and quantitatively described d The effects of the drug trastuzumab (Herceptin) are directly visualize...

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