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Dissecting Effects of Anti-cancer Drugs and Cancer-Associated Fibroblasts by On-Chip Reconstitution of Immunocompetent Tumor Microenvironments

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Nguyen, Marie | de Ninno, Adele | Mencattini, Arianna | Mermet-Meillon, Fanny | Fornabaio, Giulia | Evans, Sophia | Cossutta, Mélissande | Khira, Yasmine | Han, Weijing | Sirven, Philemon | Pelon, Floriane | Di Giuseppe, Davide | Bertani, Francesca Romana | Gerardino, Annamaria | Yamada, Ayako | Descroix, Stephanie | Soumelis, Vassili | Mechta-Grigoriou, Fatima | Zalcman, Gérard | Camonis, Jacques | Martinelli, Eugenio | Businaro, Luca | Parrini, Maria Carla

Edité par CCSD ; Elsevier Inc -

International audience. Graphical Abstract Highlights d A complex HER2 + breast cancer ecosystem is reconstituted and quantitatively described d The effects of the drug trastuzumab (Herceptin) are directly visualized ex vivo d Trastuzumab promotes long cancer-immune interactions and an ADCC immune response d Trastuzumab and CAFs have antagonist immunomodulation effects In Brief Inspired by the emerging technology of tumor-on-chip, Nguyen et al. reconstituted ex vivo a human tumor microenvironment (HER2 + breast cancer), characterized the ecosystem-level responses to the drug trastuzumab (Herceptin), and dissected the roles of stromal components (immune cells and fibroblasts), demonstrating the power of immunocompetent tumors-on-chip for preclinical drug studies.

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