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Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-alpha

Archive ouverte | Bourguet, William | CCSD

The crystal structure of the human retinoid-X receptor RXR-alpha ligand-binding domain reveals a previously undiscovered fold of an antiparallel alpha-helical sandwich, packed as dimeric units. Two helices and one loop form the ho...

A canonical structure for the ligand-binding domain of nuclear receptors

Archive ouverte | Wurtz, Jean-Marie | CCSD

Erratum : https://www.nature.com/articles/nsb0296-206. International audience

Crystal structure of a heterodimeric complex of RAR and RXR ligand-binding domains

Archive ouverte | Bourguet, William | CCSD

The crystal structure of a heterodimer between the ligand-binding domains (LBDs) of the human RARalpha bound to a selective antagonist and the constitutively active mouse RXRalphaF318A mutant shows that, pushed by a bulky extensio...

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