Crystal structure of a heterodimeric complex of RAR and RXR ligand-binding domains

Archive ouverte | Bourguet, William | CCSD

The crystal structure of a heterodimer between the ligand-binding domains (LBDs) of the human RARalpha bound to a selective antagonist and the constitutively active mouse RXRalphaF318A mutant shows that, pushed by a bulky extensio...

Structural basis for engineering of retinoic acid receptor isotype-selective agonists and antagonists

Archive ouverte | Géhin, Martine | CCSD

International audience. BACKGROUND: Many synthetic retinoids have been generated that exhibit a distinct pattern of agonist/antagonist activities with the three retinoic acid receptors (RARalpha, RARbeta and RARgamm...

Molecular determinants for agonist and antagonist binding to steroid nuclear receptors

Archive ouverte | Wurtz, Jean-Marie | CCSD