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A catalog of numerical centrosome defects in epithelial ovarian cancers
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Edité par CCSD ; Wiley Open Access -
International audience. Centrosome amplification, the presence of more than two centrosomes in a cell is a common feature of most human cancer celllines. However, little is known about centrosome numbers inhuman cancers and whether amplification or other numericalaberrations are frequently present. To address this question, wehave analyzed a large cohort of primary human epithelial ovariancancers (EOCs) from 100 patients. We found that rigorous quantitation of centrosome number in tumor samples was extremelychallenging due to tumor heterogeneity and extensive tissue disorganization. Interestingly, even if centrosome clusters could beidentified, the incidence of centrosome amplification was not comparable to what has been described in cultured cancer cells. Surprisingly, centrosome loss events where a few or many nuclei werenot associated with centrosomes were clearly noticed and overallmore frequent than centrosome amplification. Our findings highlight the difficulty of characterizing centrosome numbers inhuman tumors, while revealing a novel paradigm of centrosomenumber defects in EOCs.
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