IFCT-1502 CLINIVO: real-world evidence of long-term survival with nivolumab in a nationwide cohort of patients with advanced non-small-cell lung cancer

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Molinier, O. | Besse, B. | Barlesi, F. | Audigier-Valette, C. | Friard, S. | Monnet, I. | Jeannin, G. | Mazières, J. | Cadranel, J. | Hureaux, J. | Hilgers, W. | Quoix, E. | Coudert, B. | Moro-Sibilot, D. | Fauchon, E. | Westeel, V. | Brun, P. | Langlais, A. | Morin, F. | Souquet, P.J. | Girard, N.

Edité par CCSD ; European Society for Medical Oncology -

International audience. Background: Immunotherapy using inhibitors targeting immune checkpoint programmed cell death protein 1 (PD-1)/ programmed death-ligand 1 (PD-L1) is currently the standard of care in patients with advanced non-small-cell lung cancer (NSCLC). Materials and methods: We carried out a nationwide cohort retrospective study of consecutive patients with advanced, refractory NSCLC who received nivolumab as second to later lines of treatment as part of the expanded access program. Key objectives were to assess the efficacy and safety of nivolumab and the efficacy of first postnivolumab treatment. Results: Nine hundred and two patients were enrolled: 317 (35%) with squamous cell carcinoma and 585 (65%) with nonsquamous cell carcinoma. Median age was 64 years; there were 630 (70%) men, 795 (88%) smokers, 723 (81%) patients with an Eastern Cooperative Oncology Group (ECOG) performance status (PS) of 0/1, 197 (22%) patients with brain metastases, and 212 (27%) with liver metastases. Best response was partial response for 16.2% and stable disease (SD) for 30.5%. Progression-free survival and overall survival (OS) rates at 2, 3, and 5 years were 8% and 25%, 6% and 16%, and 4% and 10%, respectively. At multivariate analysis, ECOG PS !2 [hazard ratio (HR) ¼ 2.13, 95% confidence interval (95% CI) 1.78-2.55, P < 0.001], squamous histology (HR ¼ 1.17, 95% CI 1.01-1.36, P ¼ 0.04), and presence of central nervous system metastases (HR ¼ 1.29, 95% CI 1.08-1.54, P ¼ 0.005) were significantly associated with lower OS. Four hundred and ninety-two patients received at least one treatment after discontinuation of nivolumab, consisting of systemic therapies in 450 (91%). Radiation therapy was delivered to 118 (24%) patients. Conclusion: The CLINIVO cohort represents the largest real-world evidence cohort with the use of immune checkpoint inhibitor in advanced, metastatic NSCLC after failure of first-line chemotherapy, with long-term follow-up and analysis of subsequent therapies. Our data confirm the efficacy of nivolumab in a cohort larger than that reported in landmark clinical trials and identify prognostic factors, which reinforces the need for accurate selection of patients for treatment with immune checkpoint inhibitors. Our data indicate that oligoprogression is frequent after nivolumab exposure and provide a unique insight into the long-term survival.

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