Specific Hippocampal Interneurons Shape Consolidation of Recognition Memory

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Oliveira da Cruz, Jose F. | Busquets-Garcia, Arnau | Zhao, Zhe | Varilh, Marjorie | Lavanco, Gianluca | Bellocchio, Luigi | Robin, Laurie | Cannich, Astrid | Julio-Kalajzić, Francisca | Lesté-Lasserre, Thierry | Maître, Marlène | Drago, Filippo | Marsicano, Giovanni | Soria-Gómez, Edgar

Edité par CCSD ; Elsevier Inc -

International audience. A complex array of inhibitory interneurons tightly controls hippocampal activity, but how such diversity specifically affects memory processes is not well understood. We find that a small subclass of type 1 cannabinoid receptor (CB1R)-expressing hippocampal interneurons determines episodic-like memory consolidation by linking dopamine D1 receptor (D1R) signaling to GABAergic transmission. Mice lacking CB1Rs in D1-positive cells (D1-CB1-KO) display impairment in long-term, but not short-term, novel object recognition memory (NOR). Re-expression of CB1Rs in hippocampal D1R-positive cells rescues this NOR deficit. Learning induces an enhancement of in vivo hippocampal long-term potentiation (LTP), which is absent in mutant mice. CB1R-mediated NOR and the associated LTP facilitation involve local control of GABAergic inhibition in a D1-dependent manner. This study reveals that hippocampal CB1R-/D1R-expressing interneurons control NOR memory, identifying a mechanism linking the diversity of hippocampal interneurons to specific behavioral outcomes.

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