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Structural and Functional Analysis of E6 Oncoprotein: Insights in the Molecular Pathways of Human Papillomavirus-Mediated Pathogenesis

Archive ouverte | Nominé, Yves | CCSD

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Structural and functional analysis of E6 oncoprotein: insights in the molecular pathways of human papillomavirus-mediated pathogenesis.

Archive ouverte | Nominé, Yves | CCSD

Oncoprotein E6 is essential for oncogenesis induced by human papillomaviruses (HPVs). The solution structure of HPV16-E6 C-terminal domain reveals a zinc binding fold. A model of full-length E6 is proposed and analyzed in the cont...

HPV oncoprotein E6 is a structure-dependent DNA-binding protein that recognizes four-way Junctions † †This work is dedicated to the memory of Jean-François Lefèvre. 2 2Edited by M. Yaniv

Archive ouverte | Ristriani, Tutik | CCSD

International audience

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