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Colitis development during the suckling-weaning transition in mucin Muc2-deficient mice

Archive ouverte | Burger-van Paassen, Nanda | CCSD

International audience. The mucin Muc2 is the structural component of the colonic mucus layer. Adult Muc2 knockout (Muc2 −/− ) mice suffer from severe colitis. We hypothesized that Muc2 deficiency induces inflammati...

Mucin Muc2 Deficiency and Weaning Influences the Expression of the Innate Defense Genes Reg3b, Reg3c and Angiogenin-4

Archive ouverte | Burger-van Paassen, Nanda | CCSD

International audience. Background: Mucin Muc2 is the structural component of the intestinal mucus layer. Absence of Muc2 leads to loss of this layer allowing direct bacterial-epithelial interactions. We hypothesize...

Combined defects in epithelial and immunoregulatory factors exacerbate the pathogenesis of inflammation: mucin 2-interleukin 10-deficient mice

Archive ouverte | van Der Sluis, Maria | CCSD

International audience

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