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Colitis development during the suckling-weaning transition in mucin Muc2-deficient mice

Archive ouverte | Burger-van Paassen, Nanda | CCSD

International audience. The mucin Muc2 is the structural component of the colonic mucus layer. Adult Muc2 knockout (Muc2 −/− ) mice suffer from severe colitis. We hypothesized that Muc2 deficiency induces inflammati...

Forkhead box transcription factors Foxa1 and Foxa2 are important regulators of Muc2 mucin expression in intestinal epithelial cells

Archive ouverte | van Der Sluis, Maria | CCSD

International audience. The mucin Muc2 is the main component of the intestinal mucus layer and thus plays important roles in intestinal protection. Therefore, it is important to understand its regulation during gobl...

Colonic gene expression patterns of mucin muc2 knockout mice reveal various phases in colitis development1

Archive ouverte | Lu, Peng | CCSD

International audience

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