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Cdr1p highlights the role of the non-hydrolytic ATP-binding site in driving drug translocation in asymmetric ABC pumps

Archive ouverte | Banerjee, Atanu | CCSD

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Spontaneous suppressors against debilitating transmembrane mutants of Ca Mdr1 disclose novel interdomain communication via Signature motifs of the Major Facilitator Superfamily

Archive ouverte | Sharma, Suman | CCSD

ABSTRACT The Major Facilitator Superfamily (MFS) includes multiple families of proteins operating as uniporters, symporters and antiporters for a wide spectrum of substrates. Among them, the multidrug resistance-1 drug:H + antipor...

Suppressor genetics reveals novel inter-domain crosstalk within the multidrug transporter Mdr1 protein

Archive ouverte | Sharma, Suman | CCSD

International audience. The Multidrug resistance-1 protein (Mdr1p) of Candida albicans is a crucial drug/H+ antiporter within the Major Facilitator Superfamily of proteins involved in the efflux of a broad spectrum ...

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