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Directed Mutational Strategies Reveal Drug Binding and Transport by the MDR Transporters of Candida albicans

Archive ouverte | Banerjee, Atanu | CCSD

International audience. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY

Molecular Basis of Substrate Polyspecificity of the Candida albicans Mdr1p Multidrug/H+ Antiporter

Archive ouverte | Redhu, Archana Kumari | CCSD

International audience. The molecular basis of polyspecificity of Mdr1p, a major drug/H + antiporter of Candida albicans, is not elucidated. We have probed the nature of the drug-binding pocket by performing systema...

Spontaneous suppressors against debilitating transmembrane mutants of Ca Mdr1 disclose novel interdomain communication via Signature motifs of the Major Facilitator Superfamily

Archive ouverte | Sharma, Suman | CCSD

ABSTRACT The Major Facilitator Superfamily (MFS) includes multiple families of proteins operating as uniporters, symporters and antiporters for a wide spectrum of substrates. Among them, the multidrug resistance-1 drug:H + antipor...

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