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Engineered niches support the development of human dendritic cells in humanized mice

Archive ouverte | Anselmi, Giorgio | CCSD

International audience. Classical dendritic cells (cDCs) are rare sentinel cells specialized in the regulation of adaptive immunity. Modeling cDC development is crucial to study cDCs and harness their therapeutic po...

Transcriptional and Functional Analysis of CD1c+ Human Dendritic Cells Identifies a CD163+ Subset Priming CD8+CD103+ T Cells

Archive ouverte | Bourdely, Pierre | CCSD

International audience. Highlights d DC3s are phenotypic and functional intermediates between cDC2s and monocytes d GM-CSF alone, but not FLT3L, supports efficient differentiation of DC3s d DC3s do not differentiate...

Tissue-resident FOLR2 + macrophages associate with tumor-infiltrating CD8 + T cells and with increased survival of breast cancer patients

Archive ouverte | Ramos, Rodrigo Nalio | CCSD

SUMMARY Macrophage infiltration is a hallmark of solid cancers and overall macrophage infiltration is correlated with lower patient survival and resistance to therapy. However, tumor-associated macrophages are phenotypically and f...

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