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Mec1 Is Activated at the Onset of Normal S Phase by Low-dNTP Pools Impeding DNA Replication

Archive ouverte | Forey, Romain | CCSD

International audience. Highlights d The firing of early replication origins activates Mec1 ATR d The upregulation of dNTP pools prevents Mec1 ATR activation d Mec1 ATR triggers dNTP synthesis to complete S phase d ...

MRX Increases Chromatin Accessibility at Stalled Replication Forks to Promote Nascent DNA Resection and Cohesin Loading

Archive ouverte | Delamarre, Axel | CCSD

International audience. The recovery of stalled replication forks depends on the controlled resection of nascent DNA and on the loading of cohesin. These processes operate in the context of nascent chromatin, but th...

qDSB-Seq is a general method for genome-wide quantification of DNA double-strand breaks using sequencing

Archive ouverte | Zhu, Yingjie | CCSD

International audience. DNA double-strand breaks (DSBs) are among the most lethal types of DNA damage and frequently cause genome instability. Sequencing-based methods for mapping DSBs have been developed but they a...

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