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Mec1 Is Activated at the Onset of Normal S Phase by Low-dNTP Pools Impeding DNA Replication

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Forey, Romain | Poveda, Ana | Sharma, Sushma | Barthe, Antoine | Padioleau, Ismaël | Renard, Claire | Lambert, Robin | Skrzypczak, Magdalena | Ginalski, Krzysztof | Lengronne, Armelle | Chabes, Andrei | Pardo, Benjamin | Pasero, Philippe

Edité par CCSD ; Cell Press -

International audience. Highlights d The firing of early replication origins activates Mec1 ATR d The upregulation of dNTP pools prevents Mec1 ATR activation d Mec1 ATR triggers dNTP synthesis to complete S phase d Rad53 prevents fork collapse during dNTP shortage

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