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Distinct roles for PARP-1 and PARP-2 in c-Myc-driven B-cell lymphoma in mice

Archive ouverte | Galindo-Campos, Miguel | CCSD

International audience. Dysregulation of the c-Myc oncogene occurs in a wide variety of haematologic malignancies and its overexpression has been linked with aggressive tumour progression. Here, we show that Poly (A...

Coordinated signals from the DNA repair enzymes PARP-1 and PARP-2 promotes B-cell development and function

Archive ouverte | Galindo-Campos, Miguel | CCSD

International audience. Poly (ADP-ribose) polymerase (PARP)-1 and PARP-2 regulate the function of various DNA-interacting proteins by transferring ADP-ribose emerging from catalytic cleavage of cellular β-NAD+. Henc...

PARP-1/PARP-2 double deficiency in mouse T cells results in faulty immune responses and T lymphomas

Archive ouverte | Navarro, Judith | CCSD

International audience. The maintenance of T-cell homeostasis must be tightly regulated. Here, we have identified a coordinated role of Poly(ADP-ribose) polymerase-1 (PARP-1) and PARP-2 in maintaining T-lymphocyte n...

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