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Heterochromatin replication goes hand in hand with telomere protection

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Mendez-Bermudez, Aaron | Giraud-Panis, M.J. | Ye, Jing | Gilson, Eric

Edité par CCSD ; Nature Publishing Group -

International audience. Telomeres arose from the need to stabilize natural chromosome ends, resulting in terminal chromatin structures with specific protective functions. Their constituent proteins also execute global functions within heterochromatin, where they mediate late replication and facilitate fork progression. Emerging insights into the mechanisms governing heterochromatin replication suggest concerted actions between telomeres and heterochromatin during development and aging. They also suggest a common evolutionary origin of these two chromosome regions during eukaryogenesis.

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