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The Telomeric Protein TRF2 Regulates Replication Origin Activity within Pericentromeric Heterochromatin

Archive ouverte | Bauwens, Serge | CCSD

International audience. Heterochromatic regions render the replication process particularly difficult due to the high level of chromatin compaction and the presence of repeated DNA sequences. In humans, replication ...

TRF2-Mediated Control of Telomere DNA Topology as a Mechanism for Chromosome-End Protection.

Archive ouverte | Benarroch-Popivker, Delphine | CCSD

International audience. The shelterin proteins protect telomeres against activation of the DNA damage checkpoints and recombinational repair. We show here that a dimer of the shelterin subunit TRF2 wraps ∼ 90 bp of ...

TRF2 inhibits a cell-extrinsic pathway through which natural killer cells eliminate cancer cells

Archive ouverte | Biroccio, Annamaria | CCSD

International audience. Dysfunctional telomeres suppress tumour progression by activating cell-intrinsic programs that lead to growth arrest. Increased levels of TRF2, a key factor in telomere protection, are observ...

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