Metal Nanoclusters for Biomedical Applications: Toward In Vivo Studies. anoclusters métalliques pour les applications biomédicales : Vers des études in vivo

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Porret, Estelle | Le Guével, Xavier | Coll, Jean-Luc

Edité par CCSD ; Royal Society of Chemistry -

International audience. In parallel with the rapidly growing and widespread use of nanomedicine in the clinic, we are also witnessing the development of so-called theranostic agents that combine diagnostic and therapeutic properties. Among them, ultra-small gold nanoclusters (Au NCs) are showing promising potential due to their optical properties and activatable therapeutic activities under irradiation. Furthermore, due to their size smaller than 6 nm and unique biophysical properties, they also present intriguing behaviors in biological and physio-pathological environments. In this review, we aim to present the last researches published on such nanoparticles in animals. We also propose guidelines to identify the main physico-chemical parameters that govern Au NCs behavior after administration in small animals, notably concerning their renal elimination and their ability to accumulate in tumors. Then, we present recent advances for their use as theranostic agents putting them in parallel with others contrast agents.

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