Afficher la couverture 'Gold nanoclusters as a contrast agent for image-guided surgery of head and neck tumors | Colombé, Cindy' en grand format
/5

0 avis

Gold nanoclusters as a contrast agent for image-guided surgery of head and neck tumors

Archive ouverte

Colombé, Cindy | Le Guével, Xavier | Martín-Serrano, Angela | Henry, Maxime | Porret, Estelle | Comby-Zerbino, Clothilde | Antoine, Rodolphe | Atallah, Ihab | Busser, Benoit | Coll, Jean-Luc | Righini, Christian Adrien | Sancey, Lucie

Edité par CCSD ; Elsevier -

International audience. With the objective to evaluate the potential of ultra-small gold (Au) nanoclusters (NCs) for optical image-guided surgery, we synthesized and characterized AuNCs shelled by zwitterionic or pegylated ligands. The toxicity of the different AuNCs was evaluated on the Head and Neck Squamous Cell Carcinoma (HNSCC) CAL-33 and SQ20B cell lines in vitro. The safer AuNCs were administrated intravenously to mice for the determination of the pharmacokinetic properties. Biodistributions were performed on orthotopic CAL-33 HNSCC-bearing mice. Finally, the AuNCs were used for image-guided surgery, allowing the increase of the survival time vs. control animals, and the number of animals without any local recurrence.

Suggestions

Du même auteur

Zwitterion functionalized gold nanoclusters for multimodal near infrared fluorescence and photoacoustic imaging

Archive ouverte | Shen, Danjin | CCSD

International audience. Gold nanoclusters (Au NCs) are an emerging type of theranostic agents combining therapeutic and imaging features with reduced toxicity. Au NCs stabilized by a zwitterion ligand with a fine co...

Surface functionalization of gold nanoclusters with arginine: a trade-off between microtumor uptake and radiotherapy enhancement

Archive ouverte | Broekgaarden, Mans | CCSD

International audience

Augmented interaction of multivalent arginine coated gold nanoclusters with lipid membranes and cells

Archive ouverte | Porret, Estelle | CCSD

International audience. A library of ultra-small red photoluminescent gold nanoclusters (Au NCs) were synthesized with an increasing amount of positive charges provided by the addition of mono-, di-or trivalent-glut...

Chargement des enrichissements...