Afficher la couverture 'Evolutionary conservation of Notch signaling inhibition by TMEM131L overexpression | Szuplewski, Sebastien' en grand format
/5

0 avis

Evolutionary conservation of Notch signaling inhibition by TMEM131L overexpression

Archive ouverte

Szuplewski, Sebastien | Maharzi, Nesrine | Nelson, Elisabeth | Alhaj Hussen, Kutaiba | Mignotte, Bernard | Guenal, Isabelle | Canque, Bruno

Edité par CCSD ; Elsevier -

International audience. Human KIAA0922/TMEM131L encodes a transmembrane protein, TMEM131L, that regulates the canonical Wnt/b-catenin signaling pathway by eliciting the lysosome-dependent degradation of phosphorylated LRP6 co-receptor. Here, we use a heterospecific Drosophila transgenic model to examine the potential evolutionary conservation of TMEM131L function. Analysis of TMEM131L transgenic flies shows that TMEM131L interference with the Wnt pathway results primarily from a Notch-dependent decrease in Wingless production. Consistently, lentivirus-mediated overexpression of TMEM131L in human CD34 þ hematopoietic progenitor cells leads to decreased susceptibility to Notch1 ligation and defective commitment toward the T lineage. These results show that TMEM131L corresponds to an evolutionary conserved regulator of the Notch signaling pathway.

Suggestions

Du même auteur

Distinct subsets of multi-lymphoid progenitors support ontogeny-related changes in human lymphopoiesis

Archive ouverte | Keita, Seydou | CCSD

International audience. Changes in lymphocyte production patterns occurring across human ontogeny remain poorly defined. In this study, we demonstrate that human lymphopoiesis is supported by three waves of embryoni...

Multimodal cartography of human lymphopoiesis reveals B and T/NK/ILC lineages are subjected to differential regulation

Archive ouverte | Alhaj Hussen, Kutaiba | CCSD

International audience. The developmental cartography of human lymphopoiesis remains incompletely understood. Here, we establish a multimodal map demonstrating that lymphoid specification follows independent direct ...

Molecular and Functional Characterization of Lymphoid Progenitor Subsets Reveals a Bipartite Architecture of Human Lymphopoiesis.

Archive ouverte | Alhaj Hussen, Kutaiba | CCSD

International audience. The classical model of hematopoiesis established in the mouse postulates that lymphoid cells originate from a founder population of common lymphoid progenitors. Here, using a modeling approac...

Chargement des enrichissements...