Afficher la couverture 'Limited polymorphisms in k13 gene in Plasmodium falciparum isolates from Dakar, Senegal in 2012–2013 | Torrentino-Madamet, Marylin' en grand format
/5

0 avis

Limited polymorphisms in k13 gene in Plasmodium falciparum isolates from Dakar, Senegal in 2012–2013

Archive ouverte

Torrentino-Madamet, Marylin | Fall, Bécaye | Benoit, Nicolas | Camara, Cheikhou | Amalvict, Remy | Fall, Mansour | Dionne, Pierre | Ba Fall, Kadidiatou | Nakoulima, Aminata | Diatta, Bakary | Diemé, Yaya | Ménard, Didier | Wade, Boubacar | Pradines, Bruno

Edité par CCSD ; BioMed Central -

International audience. The emergence of Plasmodium falciparum resistance to artemisinin and its derivatives, manifested as delayed parasite clearance following the treatment, has developed in Southeast Asia. The spread of resistance to artemisinin from Asia to Africa may be catastrophic for malaria control and elimination worldwide. Recently, mutations in the propeller domain of the Kelch 13 (k13) gene (PF3D71343700) were associated with in vitro resistance to artemisinin and with delayed clearance after artemisinin treatment in southern Asia. The aim of the study was to characterize the genetic variability of k13 and to evaluate the molecular resistance to artemisinin for the first time in Senegal.

Suggestions

Du même auteur

Emergence of Mutations in the K13 Propeller Gene of Plasmodium falciparum Isolates from Dakar, Senegal, in 2013-2014

Archive ouverte | Boussaroque, Agathe | CCSD

International audience. The kelch 13 (K13) propeller gene is associated with artemisinin resistance. In a previous work, there were no mutations found in 138 Plasmodium falciparum isolates collected in 2012 and 2013...

Plasmodium falciparum susceptibility to standard and potential anti-malarial drugs in Dakar, Senegal, during the 2013–2014 malaria season

Archive ouverte | Fall, Bécaye | CCSD

International audience. Background: In 2006, the Senegalese National Malaria Control Programme recommended artemisinin-based combination therapy (ACT) as the first-line treatment for uncomplicated malaria. Since the...

Association between Polymorphisms in the Pfmdr6 Gene and Ex Vivo Susceptibility to Quinine in Plasmodium falciparum Parasites from Dakar, Senegal

Archive ouverte | Gendrot, Mathieu | CCSD

International audience. Polymorphisms and the overexpression of transporter genes, especially of the ATP-binding cassette superfamily, have been involved in antimalarial drug resistance. The objective of this study ...

Chargement des enrichissements...