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Emergence of Mutations in the K13 Propeller Gene of Plasmodium falciparum Isolates from Dakar, Senegal, in 2013-2014

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Boussaroque, Agathe | Fall, Bécaye | Madamet, Marylin | Camara, Cheikhou | Benoit, Nicolas | Fall, Mansour | Nakoulima, Aminata | Dionne, Pierre | Fall, Kadidiatou Ba | Diatta, Bakary | Diemé, Yaya | Wade, Boubacar | Pradines, Bruno

Edité par CCSD ; American Society for Microbiology -

International audience. The kelch 13 (K13) propeller gene is associated with artemisinin resistance. In a previous work, there were no mutations found in 138 Plasmodium falciparum isolates collected in 2012 and 2013 from patients residing in Dakar, Senegal (M. Torrentino-Madamet et al., Malar J 13: 472, 2014, http://dx.doi.org/10.1186/1475-2875-13-472). However, the N554H, Q613H, and V637I mutations were identified in the propeller region of K13 in 92 (5.5%) isolates in 2013 and 2014. There were five polymorphisms identified in the Plasmodium/Apicomplexa-specific domain (K123R, N137S, N142NN/NNN, T149S, and K189T/N).

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