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Modeling epigenome folding: formation and dynamics of topologically associated chromatin domains

Archive ouverte | Jost, Daniel | CCSD

International audience. Genomes of eukaryotes are partitioned into domains of functionally distinct chromatin states. These domains are stably inherited across many cell generations and can be remodeled in response ...

Single-cell absolute contact probability detection reveals chromosomes are organized by multiple low-frequency yet specific interactions

Archive ouverte | Cattoni, Diego | CCSD

International audience. At the kilo- to megabase pair scales, eukaryotic genomes are partitioned into self-interacting modules or topologically associated domains (TADs) that associate to form nuclear compartments. ...

IC-Finder: inferring robustly the hierarchical organization of chromatin folding

Archive ouverte | Haddad, Noelle | CCSD

International audience. The spatial organization of the genome plays a crucial role in the regulation of gene expression. Recent experimental techniques like Hi-C have emphasized the segmentation of genomes into int...

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