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A novel anxiogenic role for the delta opioid receptor expressed in GABAergic forebrain neurons

Archive ouverte | Chu Sin Chung, Paul | CCSD

International audience. BACKGROUND: The delta opioid receptor (DOR) is broadly expressed throughout the nervous system; it regulates chronic pain, emotional responses, motivation, and memory. Neural circuits underly...

Deletion of the mu opioid receptor gene in mice reshapes the reward–aversion connectome

Archive ouverte | Mechling, Anna E. | CCSD

Connectome genetics seeks to uncover how genetic factors shape brain functional connectivity; however, the causal impact of a single gene's activity on whole-brain networks remains unknown. We tested whether the sole targeted dele...

TouchScreen-based phenotyping: altered stimulus/reward association and lower perseveration to gain a reward in mu opioid receptor knockout mice

Archive ouverte | Boulos, Laura-Joy | CCSD

While the contribution of Mu Opioid Receptors (MORs) to hedonic aspects of reward processing is well-established, the notion that these receptors may also regulate motivation to gain a reward, and possibly other related cognitive ...

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