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Activation of the aryl hydrocarbon receptor decreases rifampicin-induced CYP3A4 expression in primary human hepatocytes and HepaRG

Archive ouverte | Rasmussen, Martin Krøyer | CCSD

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Sex dictates the constitutive expression of hepatic cytochrome P450 isoforms in Göttingen minipigs

Archive ouverte | Rasmussen, Martin Krøyer | CCSD

International audience. The cytochrome P450 enzyme (CYP) family includes key enzymes for the metabolism of drugs and xenobiotics. Several animal models have been used to determine the metabolite profile of specific ...

Skatole (3-Methylindole) Is a Partial Aryl Hydrocarbon Receptor Agonist and Induces CYP1A1/2 and CYP1B1 Expression in Primary Human Hepatocytes

Archive ouverte | Rasmussen, Martin Krøyer | CCSD

International audience. Skatole (3-methylindole) is a product of bacterial fermentation of tryptophan in the intestine. A significant amount of skatole can also be inhaled during cigarette smoking. Skatole is a pulm...

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