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Primary hepatocytes isolated from human and porcine donors display similar patterns of cytochrome p450 expression following exposure to prototypical activators of AhR, CAR and PXR

Archive ouverte | Gerbal-Chaloin, Sabine | CCSD

International audience. The hepatic cytochrome p450's (CYP) are of major importance for the metabolism of xenobiotics and knowledge about their regulation is crucial. This knowledge often originates from cell models...

Sex dictates the constitutive expression of hepatic cytochrome P450 isoforms in Göttingen minipigs

Archive ouverte | Rasmussen, Martin Krøyer | CCSD

International audience. The cytochrome P450 enzyme (CYP) family includes key enzymes for the metabolism of drugs and xenobiotics. Several animal models have been used to determine the metabolite profile of specific ...

Skatole (3-Methylindole) Is a Partial Aryl Hydrocarbon Receptor Agonist and Induces CYP1A1/2 and CYP1B1 Expression in Primary Human Hepatocytes

Archive ouverte | Rasmussen, Martin Krøyer | CCSD

International audience. Skatole (3-methylindole) is a product of bacterial fermentation of tryptophan in the intestine. A significant amount of skatole can also be inhaled during cigarette smoking. Skatole is a pulm...

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