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Archive ouverte | Myllykallio, Hannu | CCSD

International audience. Naphthoquinones (NQs) are natural and synthetic compounds with a wide range of biological activities commonly attributed to their redox activity and/or chemical reactivity. However, genetic a...

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Archive ouverte | Becker, Hubert, F | CCSD

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Archive ouverte | Becker, Hubert f. | CCSD

International audience. Thymidylate synthase ThyX, required for DNA synthesis in many pathogenic bacteria, is considered a promising antimicrobial target. It binds FAD and three substrates, producing dTMP (2′-deoxyt...

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