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Sig1R Protein Regulates hERG Channel Expression through a Post-translational Mechanism in Leukemic Cells

Archive ouverte | Crottès, David | CCSD

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The sigma-1 receptor: a regulator of cancer cell electrical plasticity?

Archive ouverte | Crottès, David | CCSD

International audience. Originally mistaken as an opioid receptor, the sigma-1 receptor (Sig1R) is a ubiquitous membrane protein that has been involved in many cellular processes. While the precise function of Sig1R...

Sigma 1 receptor regulates HERG channel expression through a post-translational mechanism in leukemic cells.

Archive ouverte | Crottes, David | CCSD

International audience. Sigma-1 receptor (Sig1R) is a 25-kDa protein structurally unrelated to other mammalian proteins. Sig1R is present in brain, liver, and heart and is overexpressed in cancer cells. Studies usin...

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