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Inactivation of the ybdD Gene in Lactococcus lactis Increases the Amounts of Exported Proteins. Inactivation of the ybdD Gene in Lactococcus lactis Increases the Amounts of Exported Proteins: Inactivation of the ybdD Gene in Lactococcus lactis Increases the Amounts of Exported Proteins

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Morello, Eric, E. | Nouaille, Sébastien | Cortes-Perez, Naima G. | Blugeon, Sebastien | Medina, Luis Fernando | Azevedo, V | Gratadoux, Jean-Jacques | Bermudez Humaran, Luis | Le Loir, Yves | Langella, Philippe

Edité par CCSD ; American Society for Microbiology -

Random insertional mutagenesis performed on a Lactococcus lactis reporter strain led us to identify L. lactis ybdD as a proteinoverproducing mutant. In different expression contexts, the ybdD mutant shows increased levels of exported proteins and therefore constitutes a new and attractive heterologous protein production host. This study also highlights the importance of unknownregulatory processes that play a role during protein secretion.

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