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IMP-29, a novel IMP-type metallo-β-lactamase in Pseudomonas aeruginosa.

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Jeannot, Katy | Poirel, Laurent | Robert-Nicoud, Marjorie | Cholley, Pascal | Nordmann, Patrice | Plésiat, Patrick

Edité par CCSD ; American Society for Microbiology -

International audience. Analysis of two clonally related multiresistant Pseudomonas aeruginosa isolates led to the identification of a novel IMP-type metallo-β-lactamase. IMP-29 was significantly different from the other IMP variants (the closest variant being IMP-5 with 93% amino acid identity). The bla(IMP-29) gene cassette was carried by a class 1 integron in strain 10.298, while in strain 10.266 it was located in a rearranged DNA region on a 30-kb conjugative plasmid. Biochemical analysis confirmed that IMP-29 efficiently hydrolyzed carbapenems.

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