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A Standard Numbering Scheme for Class C β-Lactamases

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Mack, Andrew | Barnes, Melissa | Taracila, Magdalena | Hujer, Andrea | Hujer, Kristine | Cabot, Gabriel | Feldgarden, Michael | Haft, Daniel | Klimke, William | van den Akker, Focco | Vila, Alejandro | Smania, Andrea | Haider, Shozeb | Papp-Wallace, Krisztina | Bradford, Patricia | Rossolini, Gian Maria | Docquier, Jean-Denis | Frère, Jean-Marie | Galleni, Moreno | Hanson, Nancy | Oliver, Antonio | Plésiat, Patrick | Poirel, Laurent | Nordmann, Patrice | Palzkill, Timothy | Jacoby, George | Bush, Karen | Bonomo, Robert

Edité par CCSD ; American Society for Microbiology -

International audience. Unlike for classes A and B, a standardized amino acid numbering scheme has not been proposed for the class C (AmpC) β-lactamases, which complicates communication in the field. Here, we propose a scheme developed through a collaborative approach that considers both sequence and structure, preserves traditional numbering of catalytically important residues (Ser 64 , Lys 67 , Tyr 150 , and Lys 315 ), is adaptable to new variants or enzymes yet to be discovered and includes a variation for genetic and epidemiological applications.

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