Afficher la couverture 'Sensory specific associations stored in the lateral amygdala allow for selective alteration of fear memories. | Diaz-Mataix, Lorenzo' en grand format
/5

0 avis

Sensory specific associations stored in the lateral amygdala allow for selective alteration of fear memories.

Archive ouverte

Diaz-Mataix, Lorenzo | Debiec, Jacek | Ledoux, Joseph E. | Doyère, Valérie

Edité par CCSD ; Society for Neuroscience -

International audience. Consolidated long-term fear memories become labile and can be disrupted after being reactivated by the presentation of the unconditioned stimulus (US). Whether this is due to an alteration of the conditioned stimulus (CS) representation in the lateral amygdala (LA) is not known. Here, we show in rats that fear memory reactivation through presentation of the aversive US, like CS presentation, triggers a process which, when disrupted, results in a selective depotentiation of CS-evoked neural responses in the LA in correlation with a selective suppression of CS-elicited fear memory. Thus, an aversive US triggers the reconsolidation of its associated predictor representation in LA. This new finding suggests that sensory-specific associations are stored in the lateral amygdala, allowing for their selective alteration by either element of the association.

Consulter en ligne

Suggestions

Du même auteur

The amygdala encodes specific sensory features of an aversive reinforcer.

Archive ouverte | Debiec, Jacek | CCSD

International audience. Studies of reconsolidation, in which retrieved memories are altered and restored, offer an approach for exploring the associative structure of fear memory. We found that exposure to the uncon...

The selectivity of aversive memory reconsolidation and extinction processes depends on the initial encoding of the Pavlovian association.

Archive ouverte | Debiec, Jacek | CCSD

International audience. In reconsolidation studies, memories are typically retrieved by an exposure to a single conditioned stimulus (CS). We have previously demonstrated that reconsolidation processes are CS-select...

Synapse-specific reconsolidation of distinct fear memories in the lateral amygdala.

Archive ouverte | Doyère, Valérie | CCSD

International audience. When reactivated, memories enter a labile, protein synthesis-dependent state, a process referred to as reconsolidation. Here, we show in rats that fear memory retrieval produces a synaptic po...

Chargement des enrichissements...