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Huntingtin Mediates Anxiety/Depression-Related Behaviors and Hippocampal Neurogenesis

Archive ouverte | Ben M'Barek, Karim | CCSD

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pARIS-htt: an optimised expression platform to study huntingtin reveals functional domains required for vesicular trafficking

Archive ouverte | Pardo, Raúl | CCSD

International audience. Huntingtin (htt) is a multi-domain protein of 350 kDa that is mutated in Huntington's disease (HD) but whose function is yet to be fully understood. This absence of information is due in part...

The serum- and glucocorticoid-induced kinase SGK inhibits mutant huntingtin-induced toxicity by phosphorylating serine 421 of huntingtin

Archive ouverte | Rangone, Hélène | CCSD

International audience. Huntington's disease (HD) is caused by abnormal polyglutamine (polyQ) expansion in the protein huntingtin. We have previously demonstrated the importance of the insulin-like growth factor I (...

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