Afficher la couverture 'pARIS-htt: an optimised expression platform to study huntingtin reveals functional domains required for vesicular trafficking | Pardo, Raúl' en grand format
/5

0 avis

pARIS-htt: an optimised expression platform to study huntingtin reveals functional domains required for vesicular trafficking

Archive ouverte

Pardo, Raúl | Molina-Calavita, Maria | Poizat, Ghislaine | Keryer, Guy | Humbert, Sandrine | Saudou, Frédéric

Edité par CCSD ; BioMed Central -

International audience. Huntingtin (htt) is a multi-domain protein of 350 kDa that is mutated in Huntington's disease (HD) but whose function is yet to be fully understood. This absence of information is due in part to the difficulty of manipulating large DNA fragments by using conventional molecular cloning techniques. Consequently, few studies have addressed the cellular function(s) of full-length htt and its dysfunction(s) associated with the disease.

Consulter en ligne

Suggestions

Du même auteur

Huntingtin Is Required for Mitotic Spindle Orientation and Mammalian Neurogenesis

Archive ouverte | Godin, Juliette | CCSD

International audience

The serum- and glucocorticoid-induced kinase SGK inhibits mutant huntingtin-induced toxicity by phosphorylating serine 421 of huntingtin

Archive ouverte | Rangone, Hélène | CCSD

International audience. Huntington's disease (HD) is caused by abnormal polyglutamine (polyQ) expansion in the protein huntingtin. We have previously demonstrated the importance of the insulin-like growth factor I (...

Huntingtin proteolysis releases non‐polyQ fragments that cause toxicity through dynamin 1 dysregulation

Archive ouverte | El-Daher, Marie-Thérèse | CCSD

International audience. Cleavage of mutant huntingtin (HTT) is an essential process in Huntington's disease (HD), an inherited neurodegenerative disorder. Cleavage generates N-ter fragments that contain the polyQ st...

Chargement des enrichissements...