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Knowledge-based design of reagentless fluorescent biosensors from recombinant antibodies

Archive ouverte | Renard, Martial | CCSD

The possibility of obtaining from any antibody a fluorescent conjugate which responds to the binding of the antigen by a variation of its fluorescence, would be of great interest in the analytical sciences and for the construction...

Harnessing MalE for the study of antigen/antibody recognitions

Archive ouverte | Bedouelle, Hugues | CCSD

International audience. The construction of hybrids between the variable fragment (Fv) of antibodies and protein MalE of Escherichia coli at the genetic level makes possible their preparation in a functional state, ...

Mapping to completeness and transplantation of a group-specific, discontinuous, neutralizing epitope in the envelope protein of dengue virus.

Archive ouverte | Lisova, Olesia | CCSD

Dengue is caused by a taxonomic group of four viruses, dengue virus types 1-4 (DENV1-DENV4). A molecular understanding of the antibody-mediated protection against this disease is critical to design safe vaccines and therapeutics. ...

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