Afficher la couverture 'Sustained G→A hypermutation during reverse transcription of an entire human immunodeficiency virus type 1 strain Vau group O genome | Vartanian, Jean Pierre' en grand format
/5

0 avis

Sustained G→A hypermutation during reverse transcription of an entire human immunodeficiency virus type 1 strain Vau group O genome

Archive ouverte

Vartanian, Jean Pierre | Henry, Michel | Wain-Hobson, Simon

Edité par CCSD ; Microbiology Society -

International audience. Two full-length human immunodeficiency virus type 1 O sequences are described, one of which was hypermutated in all regions of the genome. This indicates that the intracellular [dTTP]/[dCTP] bias conducive to G→A hypermutation may be sustained throughout the synthesis of minus-strand DNA. In turn, this suggests the possibility of mutation of host sequences.

Consulter en ligne

Suggestions

Du même auteur

High-resolution structure of an HIV-1 quasispecies

Archive ouverte | Vartanian, Jean Pierre | CCSD

International audience. Objective: To characterize an HIV-1 quasispecies in vivo at high resolution (1%) in order to determine its genetic structure.Methods: The first coding exon of tat was amplified by polymerase ...

Analysis of a library of macaque nuclear mitochondrial sequences confirms macaque origin of divergent sequences from old oral polio vaccine samples

Archive ouverte | Vartanian, Jean Pierre | CCSD

International audience. Nuclear mtDNA sequences (numts) are a widespread family of paralogs evolving as pseudogenes in chromosomal DNA [Zhang, D. E. & Hewitt, G. M. (1996) TREE 11, 247-251 and Bensasson, D., Zhang, ...

APOBEC1 and APOBEC3 cytidine deaminases as restriction factors for hepadnaviral genomes in non-humans in vivo.

Archive ouverte | Renard, Myrtille | CCSD

International audience. Reverse transcription of the hepadnavirus RNA pre-genome means that nascent cDNA may be vulnerable to genetic editing by host cell APOBEC cytidine deaminases that have specificity single-stra...

Chargement des enrichissements...